The Rare Disease Database

The most comprehensive source of rare disease information.

Rare View

60% of Tuberous Sclerosis cases are diagnosed in the first year. Diagnosis slows down considerably after the first year.

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Top 10 Rare Immunology Diseases

Measured by: Prevalence

Disease/ConditionEstimated US PrevalenceInheritanceInheritance ImageOnsetOnset ImageSourcesDisease Page
Systemic lupus erythematosus161,000-322,000AdultCDC
Sjogren's syndrome140,000-374,000N/AAllBMJ, PM, ONhttps://www.raremedicalnews.com/rarediseases/sjogren-syndrome/
Uveitis100,000-135,000Adult
Autoimmune hepatitis85,000-102,500N/AAllhttps://www.raremedicalnews.com/rarediseases/autoimmune-hepatitis/
Scleroderma75,000-85,000N/AAdulthttps://www.raremedicalnews.com/rarediseases/scleroderma/
Evans syndrome55,620-82,500N/AChildhoodImmune Registryhttps://www.raremedicalnews.com/rarediseases/evans-syndrome/
Bullous pemphigoid35,000-50,000N/AAdulthttps://www.raremedicalnews.com/rarediseases/bullous-pemphigoid/
Lupus nephritis66,500-124,000N/AAdultMultiplehttps://www.raremedicalnews.com/rarediseases/lupus-nephritis/
Autoimmune hemolytic anemia56,100-70,000Multigenic or
multifactor
Allhttps://www.raremedicalnews.com/rarediseases/autoimmune-hemolytic-anemia/
Polymyositis16,000-42,000N/AAdulthttps://www.raremedicalnews.com/rarediseases/polymyositis/
Others - Not Top 10
Granulomatosis with Polyangiitis (Wegener's)9,200-30,000N/Ahttps://www.raremedicalnews.com/rarediseases/granulomatosis-with-polyangiitis/
Hereditary angioedema6,000-8,000Autosomal
dominant
https://www.raremedicalnews.com/rarediseases/hereditary-angioedema/
Guillain-Barre syndrome4,000-10,000Multigenic
or multifactor
https://www.raremedicalnews.com/rarediseases/guillain-barre-syndrome/
Granulomatosis with polyangiitis (Churg-Strauss)4,000-8,000N/Ahttps://www.raremedicalnews.com/rarediseases/granulomatosis-with-polyangiitis/