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Disease Profile
Prolactinoma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
#N/A
Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Lactotroph adenoma; Pituitary lactotrophic adenoma; PRL-secreting pituitary adenoma;
Categories
Endocrine Diseases
Summary
Prolactinoma is a
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Amenorrhea |
Abnormal absence of menstruation
|
0000141 |
Decreased female libido |
Decreased female sex drive
|
0030018 |
Decreased fertility in females |
Reduced fertility in females
|
0000868 |
Decreased fertility in males | 0012041 | |
Female |
0000134 | |
Galactorrhea |
Spontaneous milk flow from breast
|
0100829 |
Hypogonadotropic hypogonadism | 0000044 | |
Difficulty getting a full erection
Difficulty getting an erection
[ more ] |
0000802 | |
Irregular menstruation |
Menstrual irregularity
|
0000858 |
Male hypogonadism |
Decreased function of male gonad
|
0000026 |
30%-79% of people have these symptoms | ||
Abnormal hair quantity | 0011362 | |
Adrenocorticotropic |
0011748 | |
Adrenocorticotropin deficient adrenal insufficiency | 0011735 | |
Decreased circulating ACTH level | 0002920 | |
Dyspareunia | 0030016 | |
Easy fatigability | 0003388 | |
Fatigue |
Tired
Tiredness
[ more ] |
0012378 |
Enlarged male breast
|
0000771 | |
Headache |
Headaches
|
0002315 |
Hypotension |
Low blood pressure
|
0002615 |
Osteopenia | 0000938 | |
0000939 | ||
Pallor | 0000980 | |
Pituitary hypothyroidism |
Low thyroid gland function due to abnormal pituitary gland
|
0008245 |
Progressive visual loss |
Progressive loss of vision
Progressive vision loss
Progressive visual impairment
Slowly progressive visual loss
Vision loss, progressive
Visual loss, progressive
[ more ] |
0000529 |
Secondary growth hormone deficiency | 0008240 | |
Vomiting |
Throwing up
|
0002013 |
5%-29% of people have these symptoms | ||
Bitemporal hemianopia | 0030521 | |
Blindness | 0000618 | |
Cranial nerve VI palsy | 0006897 | |
Delayed puberty |
Delayed pubertal development
Delayed pubertal growth
Pubertal delay
[ more ] |
0000823 |
Diplopia |
Double vision
|
0000651 |
Fourth cranial nerve palsy | 0007011 | |
Growth hormone excess | 0000845 | |
Internal ophthalmoplegia | 0007942 | |
Oculomotor nerve palsy | 0012246 | |
Drooping upper eyelid
|
0000508 | |
0001250 | ||
Sudden loss of visual acuity | 0001117 | |
Vertigo |
Dizzy spell
|
0002321 |
Percent of people who have these symptoms is not available through HPO | ||
Pituitary prolactin |
0006767 | |
Prolactinoma | 0040278 |
Diagnosis
Making a diagnosis for a genetic or rare disease can often be challenging. Healthcare professionals typically look at a person’s medical history, symptoms, physical exam, and laboratory test results in order to make a diagnosis. The following resources provide information relating to diagnosis and testing for this condition. If you have questions about getting a diagnosis, you should contact a healthcare professional.
Testing Resources
- The Genetic Testing Registry (GTR) provides information about the genetic tests for this condition. The intended audience for the GTR is health care providers and researchers. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.
Related diseases
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
|
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Causes of hyperprolactinemia without pituitary adenoma include: pregnancy, lactation, exercise, stress and polycystic ovary syndrome. Pituitary lesions that do not produce prolactin can also cause hyperprolactinemia by pituitary stalk impingement (stalk effect).
Visit the Orphanet disease page for more information.
|
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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Pituitary Network Association
P.O. Box 1958
Thousand Oaks, CA 91358
Telephone: +1-805-499-9973
Fax: +1-805-480-0633
E-mail: [email protected]
Website: https://pituitary.org/ -
The Pituitary Foundation
86 Colston Street
Bristol BS1 5BB
United Kingdom
Telephone: 0117 370 1320
E-mail: [email protected]
Website: https://www.pituitary.org.uk/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- Mayo Clinic has an information page on Prolactinoma.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
- The Pituitary Society has a patient education booklet on Prolactinoma with information on symptoms, diagnosis, treatment, and more.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
References
- Prolactinoma. Orphanet. February 2014; https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=2965.
- Prolactinomas. Pituitary Network Association. https://pituitary.org/knowledge-base/disorders/prolactinomas. Accessed 9/28/2016.