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Disease Profile

Lymphocytic infiltrate of Jessner

Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.


US Estimated

Europe Estimated

Age of onset






Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.


Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.


dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.


recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.


Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.


Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.


Not applicable


Other names (AKA)

Benign lymphocytic infiltration; Jessner disease; Jessner-Kanof syndrome;


Skin Diseases


Lymphocytic infiltrate of Jessner is a skin condition characterized by small, red, bumps on the face, neck, and upper back.[1][2] The bumps usually last for several months or longer and can enlarge to create a red plaque.[2] Typically, there are no other symptoms, although rarely, individuals may experience burning or itching. The symptoms may fluctuate between periods of worsening and periods of improvement.[1][2] Some cases of lymphocytic infiltrate of Jessner have been associated with borrelia infection (the bacteria that causes Lyme disease); however, in most instances, the cause is not known. Frequently, no treatment is necessary as the bumps and plaque usually spontaneously disappear.[2]


This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.

Medical Terms Other Names
Learn More:
80%-99% of people have these symptoms
Skin plaque
30%-79% of people have these symptoms
Abnormal lymphocyte morphology
Cutaneous photosensitivity
Photosensitive skin
Photosensitive skin rashes
Sensitivity to sunlight
Skin photosensitivity
Sun sensitivity

[ more ]

Itchy skin
Skin itching

[ more ]



Lymphocytic infiltrate of Jessner may require no treatment (since it can resolve spontaneously), but some patients benefit from cosmetic camouflage, photoprotection, surgery to remove small lesions, use of steroids orally or topically, antimalarial medications such as hydroxychloroquine, cryotherapy, methotrexate, thalidomide, and/or oral auranofin.[1][2]


Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

    Organizations Providing General Support

      Learn more

      These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

      Where to Start

      • The American Osteopathic College of Dermatology provides information on Lymphocytic infiltrate of Jessner.
      • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
      • The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.

        In-Depth Information

        • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
        • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
        • PubMed is a searchable database of medical literature and lists journal articles that discuss Lymphocytic infiltrate of Jessner. Click on the link to view a sample search on this topic.

          Resources for Kids


            1. Kara Melissa T Torres. Jessner lymphocytic infiltration of the skin. Medscape. Jan 12, 2015; https://emedicine.medscape.com/article/1098654-overview.
            2. Jessner lymphocytic infiltrate. DermNetNZ. September 2015; https://www.dermnetnz.org/topics/jessner-lymphocytic-infiltrate/.

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