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Disease Profile
Follicular lymphoma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-5 / 10 000
Age of onset
Adult
ICD-10
C82.0 C82.1 C82.2 C82.3 C82.4 C82.5 C82.6 C82.7 C82.9
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Lymphoma, follicular
Categories
Blood Diseases; Rare Cancers
Summary
Orpha Number: 545
Symptoms
This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
Medical Terms | Other Names |
Learn More:
HPO ID
|
---|---|---|
80%-99% of people have these symptoms | ||
Fever | 0001945 | |
Lymphoma |
Cancer of lymphatic system
|
0002665 |
Mediastinal lymphadenopathy |
Swollen lymph nodes in center of chest
|
0100721 |
Night sweats | 0030166 | |
Weight loss | 0001824 | |
30%-79% of people have these symptoms | ||
Fatigue |
Tired
Tiredness
[ more ] |
0012378 |
Splenomegaly |
Increased spleen size
|
0001744 |
5%-29% of people have these symptoms | ||
Abnormality of the peritoneum | 0002585 | |
Lymphedema |
Swelling caused by excess lymph fluid under skin
|
0001004 |
0001287 | ||
Pleural effusion |
Fluid around lungs
|
0002202 |
Skin nodule | 0200036 | |
Percent of people who have these symptoms is not available through HPO | ||
B |
0012191 | |
0001428 |
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Copanlisib(Brand name: Aliqopa) Manufactured by Bayer US LLC
FDA-approved indication: For the treatment of adult patients with relapsed follicular lymphoma who have received at least two prior systemic therapies.
National Library of Medicine Drug Information Portal - PI3K-delta and PI3K-gamma inhibitor(Brand name: Duvelisib) Manufactured by Verastem, Inc.
FDA-approved indication: September 2018, PI3K-delta and PI3K-gamma inhibitor (Duvelisib) was approved for the treatment of adult patients with relapsed or refractory chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or follicular lymphoma after at least two prior therapies.
National Library of Medicine Drug Information Portal - Obinutuzumab(Brand name: Gazyva) Manufactured by Genentech, Inc.
FDA-approved indication: Indicated for the treatment of patients with follicular lymphoma (FL) who relapsed after, or are refractory to, a rituximab containing regimen. Also treatment of patients achieving at least a partialremission as well as the treatment of adult patients with previously untreated stage II bulky, II or IV follicular lymphoma.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Rituximab and hyaluronidase human(Brand name: Rituxan Hycela) Manufactured by Genentech, Inc.
FDA-approved indication: Treatment of adult patients with relapsed or refractory, follicular lymphoma as a single agent, previously untreated follicular lymphoma in combination with first linechemotherapy and, in patients achieving a complete or partial response to rituximab in combination with chemotherapy, as single-agent maintenance therapy, non-progressing (including stable disease), follicular lymphoma as a single agent after first-line cyclophosphamide, vincristine, andprednisone (CVP) chemotherapy.
National Library of Medicine Drug Information Portal
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Follicular lymphoma. Click on the link to view a sample search on this topic.