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Disease Profile

Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

Unknown

Age of onset

-

ICD-10

C92.5

Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Other names (AKA)

AML with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22); AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11;

Categories

Blood Diseases; Rare Cancers

Summary

Acute myelomonocytic leukemia (AMML) is a cancer that typically develops in the bone marrow and blood of older individuals. AMML is one type of acute myeloid leukemia, a group of blood cancers that occur when the amount of white blood cells increases rapidly. Symptoms of AMML often include fatigue (due to anemia) or easy bruising or bleeding (due to thrombocytopenia). The cause of AMML is currently unknown. Treatment typically consists of chemotherapy.[1]

Treatment

Acute myelomonocytic leukemia (AMML) is typically treated with chemotherapy, drugs injected into the bloodstream that target and destroy cancer cells. The amount and type of chemotherapy used to treat AMML depends on the age and health of the affected individual. The first step of chemotherapy for AMML is induction therapy, treatment with drugs that aim to destroy the cancer cells in the bone marrow and blood. Induction thearpy is followed by a rest phase to allow the affected individual to recover from the initial treatments. Then, the second step of chemotherapy is given, called consolidation therapy, which should destroy any cancer cells that may remain in the body.[1] Stem cell transplant or participation in a clinical trial may also be used to treat AMML if chemotherapy treatments are unsuccessful.[2]

Learn more

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) . Click on the link to view a sample search on this topic.

References

  1. American Cancer Society. Detailed Guide. Leukemia Acute Myeloid (Myelogenous). January 2013; https://www.cancer.org/cancer/leukemia-acutemyeloidaml/detailedguide/index. Accessed 2/12/2013.
  2. National Comprehensive Cancer Network. Acute Myeloid Leukemia. NCCN Clinical Practice Guidelines in Oncology. 2013; https://www.nccn.org/professionals/physician_gls/pdf/aml.pdf.

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