Rare Immunology News

5 Facts you should know about

CRISPR

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1

CRISPRs were first discovered by Francisco Mojica, a scientist at the University of Alicante in Spain

2

CRISPRs work by harnessing the natural mechanisms of the immune systems of bacterium cells of invading viruses, which is then able to cut out infected DNA strands

3

CRISPR “spacer” sequences are transcribed into short RNA sequences that are capable of guiding the system to matching sequences of DNA

4

When the target DNA is found, Cas9 – one of the enzymes produced by the CRISPR system – binds to the DNA - and cuts it

5

Using modified versions of Cas9, researchers can then activate expression of targeted genes

Rare Immunology News