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5 Facts you should know about
Activated PI3K delta syndrome (APDS)
1
APDS, a Primary Immunodeficiency, was only characterized in 2013, although it shares many features of other immune disorders, which means APDS patients may have been previously misdiagnosed with other conditions
2
Signs and symptoms of APDS start in childhood, and patients are vulnerable to repeat infections and immune dysregulation such as sinusitis, severe respiratory tract infections, recurrent herpes or EBV/CMV, lymphadenopathy, and autoimmune cytopenias
3
Immunologists may mistake APDS for combined immunodeficiency (CID) or common variable immune deficiency (CVID) or hyper IgM syndrome (HIGM)
4
Genetic testing is the only way to definitively diagnose APDS and other primary immunodeficiencies
5
Management of APDS is symptomatic—antibiotics, antivirals, or IVIG may be used to treat or prevent recurrent infections immunodeficiencies
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